Orange.fr smtp systematically fail when Freedom is activated while there is no problem whenever Freedome is Off.
I am already using smtps with port 465 and it works with Freedome and other emails providers but not with Orange in France.
I did not find yet any hints about that reading Orange configurations instructions.
Yes, as indicated, it is working with other providers used by my wife and children but unfortunately not for me with Orange.
I am using Mail in iOS.
Just as addition for discussion. Freedome-board with some topics (partly related with your setting; some point or another point). Just examples:
I also did brief 'query' with Google Search about ""Orange.fr smtp VPN"" and there is quite many local search results (?!). Maybe such situation is popular topic. What if it can be useful to re-check such articles (but probably you already did that!).
As another suggestion -> did you try disable "Tracking Protection" or "Browsing Protection" features under Freedome? I do not able to be sure that it can be useful - but why do not try it?!