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The newest version of Process Explorer from Windows Sysinternals(a Microsoft Company) now has VirusTotal(VT) support. VT is a multi-engine scanner that includes anti-virus(AV) scanners from F-Secure, BitDefender, ESET-NOD32, Kaspersky, Malwarebytes, Microsoft, Norman, Panda, SuperAntiSpyware, Sophos, Symantec and many more.
To get this go to menu Options - VirusTotal.com - Check VirusTotal.com (if it doesn't work right away just restart Process Explorer)
Getting the results from VT is very fast because it does not send any files to VT, it just sends the file hashes. The downside with this approach is that you get the scan results for when the file was last uploaded and analyzed.
By clicking a value in the VT column the VT page for that file opens in a web browser and you can see more details like what AV detected anything and what it detected. And also the analysis date.
Edit: Found a method to send a file to VT from Process Explorer: Double-click a process. In the Image tab, click the Submit button for VirusTotal. This will re-analyze and(after a few minutes) give you an updated VT score for the file