Is it possible that F-Secure SAFE could be updated to become compatible with Windows 10 Device Guard?
It currently is not compatible with HVCI enabled (Hypervisor Enforced Code Integrity), as any Windows 10 UWP apps open and then close immediately.
The error from event log is:
App Microsoft.ZuneMusic_10.19011.11311.0_x64__8wekyb3d8bbwe was terminated with error 0xC000047E because of an issue with Windows binary \Device\HarddiskVolume6\Program Files (x86)\F-Secure\SAFE\apps\Ultralight\ulcore\1552296247\fshook64.dll. This could be because the binary is unsigned, contains an untrusted signature, or has been corrupted or tampered with. Refresh your PC to fix this issue.