Worried my machine is unsafe

I installed F-Secure Safe about a month ago, but suddenly find my machine starts running slow and the database is trying to update (! icon) when I look at the icon at the top of my mac.  I keep getting Ca't connect to server messages and orange or red (!) symbols.

Any idea what I need to do?  I try to run the antivirus, but the window doesn't even come up?  Have I got something wrong with my machine?

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